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Updated: Jul 13, 2026

High-throughput Screening for Protein-based Inheritance in S. cerevisiae

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[Elusive function of prion protein].

Naomi S Hachiya¹, Kiyotoshi Kaneko

¹Department of Neurophysiology, Tokyo Medical University.

Nihon Rinsho. Japanese Journal of Clinical Medicine

|August 19, 2007

Summary

The normal function of cellular prion protein (PrP(c)), a membrane glycoprotein, is unclear despite its role in prion diseases. Research explores its potential roles in cell survival and oxidative stress, but functional validation is ongoing.

Area of Science:

Neurobiology
Molecular Biology
Biochemistry

Context:

Cellular prion protein (PrP(c)) is a conserved glycoprotein found on cell membranes, notably in the brain, heart, and muscle.
Misfolding of PrP(c) into the infectious PrP(Sc) form is central to prion diseases.
The precise physiological function of PrP(c) remains incompletely understood.

Purpose:

To review current research on the biological functions of mammalian prion protein.
To highlight suggested roles for PrP(c) such as in oxidative stress, cell adhesion, copper uptake, and cell survival.
To underscore the need for further functional validation of identified PrP(c) interactions.

Summary:

Prion protein (PrP(c)) is a cell membrane-bound glycoprotein with an unclear normal function.

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Despite its involvement in prion infections, PrP(c) has proposed roles in cellular processes like oxidative stress defense and cell survival.

While numerous binding proteins and potential functions have been identified, experimental confirmation through functional assays is still lacking.

Impact:

Provides a consolidated overview of the current state of knowledge regarding PrP(c) function.
Identifies gaps in research and emphasizes the necessity for rigorous functional studies.
Contributes to a better understanding of prion protein biology, potentially aiding in the study of prion-related disorders.