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Updated: Feb 15, 2026

Detection of Abnormal Prion Protein by Immunohistochemistry
Published on: May 5, 2023
[Prevention of prion disease transmission]
Hitaru Kishida1, Yoshiyuki Kuroiwa
1Department of Neurology, Yokohama City University.
Abstract:
Prion infections lead to fatal diseases of the CNS, including Creutzfeldt-Jakob disease (CJD) in humans, bovine spongiform encephalopathy(BSE) in cows. Iatrogenic CJD which have been transmitted through dura-matter transplantation, administration of pituitary tissue extracts, corneal transplantation, or neurosurgical procedures. There are not thought to be infectious agents in blood of sporadic CJD patients. However three recipients of blood donated by individuals who subsequently developed variant CJD in United Kingdam. We introduce the guideline for CJD infection through medical procedure made in 2003 and arouse attention to risk of blood in variant CJD patients.
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