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Published on: September 25, 2018
Preoperative serum C-reactive protein level in non-small cell lung cancer
Masaki Hara1, Yasunori Matsuzaki, Tetsuya Shimuzu
1Department of Cardiovascular, Thoracic and General Surgery, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki, 889-1692, Japan. haramasa@med.miyazaki-u.ac.jp
Unlabelled:
We evaluated the significance of the preoperative serum C-reactive protein (CRP) level as a prognostic indicator in patients with non-small cell lung cancer (NSCLC).
Patients And Methods:
Two hundred and three patients who had undergone a curative resection of NSCLC were retrospectively reviewed.
Results:
The proportion of the tumor size over 3 cm per patient in the CRP-positive group (> or =0.5 mg/dL: n=38) was significantly higher than that in the CRP-negative group (<0.5 mg/dL: n = 165). The proportion of the adenocarcinoma in CRP-positive group was significantly lower than that in CRP-negative group. The overall and disease specific survival rates in the CRP-positive group were significantly lower than the rates in the CRP-negative group. Based on a multivariate analysis, the preoperative serum CRP level was selected as one of the unfavorable indicators regarding survival.
Conclusion:
The preoperative serum CRP level is an independent and significant indicator predictive of a poor prognosis in patients with NSCLC.
