Related Experiment Video
Updated: Jul 13, 2026

Discovery and Synthesis Optimization of Isoreticular Al(III) Phosphonate-Based Metal-Organic Framework Compounds Using High-Throughput Methods
Published on: October 6, 2023
Solid-phase supported synthesis: a possibility for rapid scale-up of chemical reactions
M Meisenbach1, T Allmendinger, C P Mak
1Chemical and Analytical Development, Novartis Pharma AG, 4002 Basel, Switzerland. mark.meisenbach@novartis.com
Abstract:
The direct scale-up of a solid-phase synthesis has been demonstrated with 4-(2-amino-6-phenylpyrimidin-4-yl)benzamide and an arylsulfonamido-substituted hydroxamic acid derivative as examples. These compounds were obtained through combinatorial chemistry and solution-phase synthesis was used in parallel to provide a comparison. By applying highly loaded polystyrene-derived resins as the solid support, a good ratio between the product and the starting resin is achieved. We have demonstrated that the synthesis can be scaled up directly on the solid support, successfully providing the desired compounds easily and quickly in sufficient quantities for early development demands.
Related Concept Videos
Fast Reactions
Reaction Mechanisms: Rate-limiting Step Approximation
Heterogeneous Catalysis
Catalysis
Synthesis and Decomposition Reactions
Chemical Reactions
Chemical Reactions Rearrange Atoms into New Substances
A chemical reaction takes starting materials—the reactants—and changes them into different...

