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Utilization of Stop-flow Micro-tubing Reactors for the Development of Organic Transformations
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Microstructured reactors for development and production in pharmaceutical and fine chemistry.

V Hessel1, P Löb, U Krtschil

  • 1Department of Chemical Engineering and Chemistry, Eindhoven University of Technology, STW 1.35, PO Box 513, 5600 MB Eindhoven, The Netherlands. v.hessel@tue.nl

Ernst Schering Foundation Symposium Proceedings
|August 19, 2007
PubMed
Summary

Microprocess technology offers significant process intensification potential, but requires exploring novel "new process windows" for broader industrial adoption beyond niche applications. This study analyzes costs and demonstrates viable industrial microflow processes using scaled-out reactors.

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Area of Science:

  • Chemical Engineering
  • Process Intensification
  • Microreactor Technology

Background:

  • The full potential of microprocess technology for process intensification remains underexplored, despite emerging industrial applications.
  • Microstructured reactors are increasingly recognized for their ability to enhance chemical processes.

Purpose of the Study:

  • To analyze the cost structure of processes utilizing microstructured reactors.
  • To identify and define novel chemical protocol conditions, termed "new process windows," tailored for microprocess technology.
  • To demonstrate the viability of industrial microflow processes through scaled-out reactor designs and case studies.

Main Methods:

  • Shortcut cost analysis to identify major cost contributors in microreactor processes.
  • Development of generic rules for "new process windows" to enable tailored chemistry.
  • Case study analysis of gas-liquid microprocessing and commercially oriented microflow applications.

Main Results:

  • Cost analysis highlights key economic factors for microstructured reactor processes.
  • Novel "new process windows" are proposed as essential for unlocking microprocess technology's potential.
  • Successful demonstration of scaled-out microreactors for industrial gas-liquid microprocessing.

Conclusions:

  • Microprocess technology, when combined with "new process windows" and scaled-out reactors, can lead to viable industrial microflow processes.
  • Without adopting these new conditions, microprocess technology is likely to remain confined to niche applications.
  • Active exploration and application of these principles are crucial for realizing the widespread benefits of microprocess intensification.