Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Classification criteria for systemic sclerosis subsets.

Sindhu R Johnson1, Brian M Feldman, Gillian A Hawker

  • 1Division of Rheumatology, University Health Network, University of Toronto, Toronto, Ontario, Canada. Sindhu.Johnson@uhn.on.ca

The Journal of Rheumatology
|August 19, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Does pain pattern matter? Association of intermittent, constant, predictable and unpredictable knee pain to patient-reported knee symptom acceptability in knee osteoarthritis.

Osteoarthritis and cartilage open·2026
Same author

Update on clinimetric assessments in juvenile dermatomyositis: conceptual foundations, current tools, and future directions : (Narrative review describing the development, validation, and application of clinimetric outcome measures in juvenile dermatomyositis).

Pediatric rheumatology online journal·2026
Same author

A scoping review of digital psychosocial interventions for sleep disturbances in children with chronic health conditions.

Sleep medicine·2026
Same author

Systematic Literature Review Informing Paediatric Rheumatology European Society/Childhood Arthritis and Rheumatology Research Alliance-Endorsed Recommendations for the Treat-to-Target Strategy in Juvenile Dermatomyositis.

The Journal of rheumatology·2026
Same author

Differentiating Periodic Fever, Aphthous Stomatitis, Pharyngitis, Cervical Adenitis (PFAPA) and Syndrome of Undifferentiated Recurrent Fever (SURF): A Comparative Study of Clinical Features, Treatment Response, and Remission.

The Journal of rheumatology·2026
Same author

Trajectories of Physical Function in Canadian Children With Juvenile Idiopathic Arthritis.

Arthritis care & research·2026
Same journal

Clinical Features and Outcome Measures Across Still Disease (Systemic Juvenile Idiopathic Arthritis and Adult-Onset Still Disease) Cohorts Worldwide: A Systematic Literature Review.

The Journal of rheumatology·2026
Same journal

Concurrent Calcium Pyrophosphate Deposition Disease and Gout of the Cervical Spine Presenting With Subacute Neck Pain and Radiculopathy.

The Journal of rheumatology·2026
Same journal

The Need for Weight Communication Guidelines in Pediatric Rheumatology.

The Journal of rheumatology·2026
Same journal

Bimekizumab Improves Health Status and Work Productivity, With Reduced Productivity Costs, to 3 Years in Axial Spondyloarthritis and Psoriatic Arthritis.

The Journal of rheumatology·2026
Same journal

Qualitative Analysis of Physical Activity Engagement in Women with Self-Reported SLE: The Role of Symptoms, Healthcare Providers, and the Environment.

The Journal of rheumatology·2026
Same journal

Tumoral Calcinosis-like Calcification of the Proximal Interphalangeal Joint Mimicking Rheumatoid Arthritis Flare.

The Journal of rheumatology·2026
See all related articles

The 2-subset criteria for systemic sclerosis (SSc) demonstrate good feasibility and predictive validity for patient classification in clinical trials. Further research is needed to compare their content and divergent validity against other SSc criteria.

Area of Science:

  • Rheumatology
  • Clinical Trial Design
  • Medical Classification Systems

Background:

  • Systemic sclerosis (SSc) classification requires robust criteria for accurate patient stratification in clinical trials.
  • Existing criteria sets for SSc subsets vary in their measurement properties.
  • Evaluating these criteria is crucial for optimizing trial design and patient selection.

Purpose of the Study:

  • To assess the measurement properties of criteria used for classifying systemic sclerosis (SSc) subsets in clinical trials.
  • To identify if any specific criteria set offers a measurement advantage over others for SSc research.

Main Methods:

  • A systematic review was conducted on published classification criteria for SSc subsets.
  • Evaluated evidence for sensibility, validity (face, content, predictive, divergent), and reliability of identified criteria sets.

Related Experiment Videos

Main Results:

  • Fourteen SSc subset classification criteria sets were identified, showing variability in purpose and application.
  • Face validity improved with more complex criteria, but feasibility decreased.
  • Most criteria lacked evaluated content validity due to undefined conceptual frameworks.
  • 2-subset criteria demonstrated comparable predictive validity to 3+ subset criteria.

Conclusions:

  • The LeRoy, et al 2-subset criteria exhibit good feasibility, acceptable face validity, and strong predictive validity for SSc classification.
  • Additional research is necessary to compare the content, divergent validity, and reliability of these criteria with other SSc subset criteria for trial use.