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The human ICAM2 gene maps to 17q23-25
D Sansom1, J Borrow, E Solomon
1Human Immunogenetics Laboratory, Imperial Cancer Research Fund, London, United Kingdom.
Genomics
|October 1, 1991
Summary
The intercellular adhesion molecule 2 (ICAM2) gene
Area of Science:
- Immunology
- Molecular Biology
- Genetics
Background:
- Intercellular adhesion molecules (ICAMs) like ICAM1 and ICAM2 are crucial for immune cell interactions.
- ICAM1 and ICAM2 bind to lymphocyte function-associated antigen LFA-1 (CD11a/CD18).
- Distinct expression patterns suggest unique roles for ICAM1 and ICAM2 in the immune system.
Purpose of the Study:
- To determine the chromosomal location of the human ICAM2 gene.
- To investigate potential distinct functional roles of ICAM2 compared to ICAM1.
Main Methods:
- Utilized a panel of somatic cell hybrids.
- Employed chromosome-mediated gene transfectants.
- Performed Southern blot hybridization with an ICAM2 cDNA clone.
Main Results:
- The human ICAM2 gene was mapped to chromosome 17.
- Specifically, the gene localizes to the q23-25 region of chromosome 17.
Conclusions:
- The chromosomal mapping of ICAM2 provides a basis for further functional studies.
- Understanding ICAM2's location aids in dissecting its specific role in immune responses.