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Interval timing in genetically modified mice: a simple paradigm.

F Balci1, E B Papachristos, C R Gallistel

  • 1Psychology Department and Rutgers Center for Cognitive Science, Rutgers University, Piscataway, NJ 08854-8020, USA. fbalci@ruccs.rutgers.edu

Genes, Brain, and Behavior
|August 19, 2007
PubMed
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We developed a new behavioral screen to measure interval timing and memory in mice. This method revealed that mice lacking a specific receptor do not have altered timing abilities, refuting a hypothesis about fear conditioning.

Area of Science:

  • Neuroscience
  • Behavioral Science
  • Animal Models

Background:

  • Interval timing and memory are crucial cognitive functions.
  • Understanding the neural basis of temporal cognition is essential.
  • Previous studies suggest altered fear responses in certain genetic mouse models.

Purpose of the Study:

  • To establish a quantitative behavioral screen for interval timing and memory in mice.
  • To investigate the role of the gastrin-releasing peptide receptor in temporal processing.
  • To validate the screen using pharmacological agents.

Main Methods:

  • Mice were trained to switch feeding stations based on elapsed time intervals.
  • Psychometric functions were used to quantify timing accuracy and precision.

Related Experiment Videos

  • Gene knockout mice (gastrin-releasing peptide receptor) were tested.
  • Pharmacological validation was performed using d-amphetamine and methamphetamine.

    • Main Results:

    • The developed behavioral screen effectively measures interval timing accuracy and precision.
    • Mice with the gastrin-releasing peptide receptor knockout exhibited normal timing accuracy and precision.
    • Pharmacological manipulations with d-amphetamine and methamphetamine demonstrated the screen's sensitivity.

    Conclusions:

    • The novel behavioral screen provides a simple and efficient method for assessing interval timing and memory.
    • The gastrin-releasing peptide receptor is not essential for normal interval timing accuracy or precision in mice.
    • This paradigm can be integrated into the assessment of learning and memory in genetically modified mice.