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[Correlation of cyclooxygenase-2 expression to P-glycoprotein expression in B-cell non-Hodgkin's lymphoma]
Bin Li1, Mei-Zuo Zhong, Tao-Fu Tang
1Department of Oncology, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, PR China. luoxiao4132@sina.com.cn
Background & Objective:
The overexpression of P-glycoprotein (P-gp) plays an important role in the chemoresistance of relapsed lymphoma. It is up-regulated in a cyclooxygenase-2 (COX-2)-dependent manner. This study was to observe the expression and correlation of COX-2 and P-gp in B-cell non-Hodgkin's lymphoma (B-NHL), and to investigate their correlations to clinicopathologic features of B-NHL.
Methods:
The expression of COX-2 and P-gp in 43 specimens of naive B-NHL and 27 specimens of relapsed B-NHL were detected by SP immunohistochemistry and reverse transcription-polymerase chain reaction (RT-PCR).
Results:
The positive rates of COX-2 and P-gp were significantly lower in naive B-NHL than in relapsed B-NHL (23.3% vs. 74.1%, 11.6% vs. 70.4%, P<0.01). COX-2 expression was positively correlated to P-gp expression in relapsed B-NHL (r=0.998, P<0.01). The positive rates of COX-2 and P-gp were significantly higher in aggressive B-NHL than in indolent B-NHL (64.3% vs. 10.7%, P=0.002; 52.4% vs. 7.1%, P=0.012).
Conclusion:
COX-2 and P-gp are highly expressed in relapsed B-NHL, and they may play a role in tumor metastasis of B-NHL.