Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Role of Hematopoietic Growth Factors

Role of Hematopoietic Growth Factors

Hematopoietic growth factors are molecules that regulate the differentiation rate of hematopoietic stem cells (HSCs). Erythropoietin (EPO), primarily produced by the kidneys, plays a crucial role in erythrocyte production. When oxygen levels in the blood are low, EPO is released into the bloodstream, reaching the bone marrow, where it stimulates HSCs to differentiate and mature into erythrocytes, which are vital for oxygen transport.
Thrombopoietin (TPO), mainly released by the liver,...

Regulation of Hematopoietic Stem Cells

Regulation of Hematopoietic Stem Cells

All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...

Hematopoiesis

Hematopoiesis

The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...

Regulation of Angiogenesis and Blood Supply

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits. Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...

Intracellular Signaling Affects Focal Adhesions

Intracellular Signaling Affects Focal Adhesions

Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...

Overview of Hematopoiesis

Overview of Hematopoiesis

Hematopoiesis, or blood cell production, is a vital biological process that begins early in embryonic development and continues throughout life. This process generates the various types of cells found in blood, including red blood cells, white blood cells, and platelets from hematopoietic stem cells (HSCs).
Developmental Phases of Hematopoiesis
Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A careful examination of large behavior models for multitask dexterous manipulation.

Science robotics·2026

Same author

Multinational physician perspectives on abortion care in the context of changing legislation.

Frontiers in global women's health·2025

Same author

Moderate Chronic Treadmill Exercise Slows Dopaminergic Neuron Loss in a Rat Model of Parkinson's Disease and Alters RNA Content of Circulating Plasma Exosomes.

Journal of neuroscience research·2025

Same author

Serial electrical cardioversion for refractory atrial fibrillation with rapid ventricular response post ablation.

International journal of emergency medicine·2025

Same author

RIG-I-dependent tumor-intrinsic type I interferon signaling restricts growth in breast cancer 3D culture.

bioRxiv : the preprint server for biology·2025

Same author

Utility of serum cytokine testing to differentiate complicated common variable immunodeficiency in resource limited settings.

The journal of allergy and clinical immunology. Global·2025

Search research articles

Related Experiment Video

Updated: Jul 13, 2026

A Novel Three-dimensional Flow Chamber Device to Study Chemokine-directed Extravasation of Cells Circulating under Physiological Flow Conditions

A Novel Three-dimensional Flow Chamber Device to Study Chemokine-directed Extravasation of Cells Circulating under Physiological Flow Conditions

Published on: July 15, 2013

Tachykinins and hematopoiesis.

Katherine Liu¹, Marianne D Castillo, Raghav G Murthy

¹Graduate School of Biomedical Sciences, UMDNJ, Newark, NJ 07103, USA.

Clinica Chimica Acta; International Journal of Clinical Chemistry

|August 19, 2007

Summary

Tachykinins and cytokines regulate blood cell formation (hematopoiesis) from bone marrow stem cells. Understanding this interaction may reveal new treatments for blood disorders like leukemia and anemia.

More Related Videos

Automated Quantification of Hematopoietic Cell – Stromal Cell Interactions in Histological Images of Undecalcified Bone

Automated Quantification of Hematopoietic Cell – Stromal Cell Interactions in Histological Images of Undecalcified Bone

Published on: April 8, 2015

Flow Cytometry Analysis of Murine Bone Marrow Hematopoietic Stem and Progenitor Cells and Stromal Niche Cells

Flow Cytometry Analysis of Murine Bone Marrow Hematopoietic Stem and Progenitor Cells and Stromal Niche Cells

Published on: September 28, 2022

Related Experiment Videos

Last Updated: Jul 13, 2026

A Novel Three-dimensional Flow Chamber Device to Study Chemokine-directed Extravasation of Cells Circulating under Physiological Flow Conditions

A Novel Three-dimensional Flow Chamber Device to Study Chemokine-directed Extravasation of Cells Circulating under Physiological Flow Conditions

Published on: July 15, 2013

Automated Quantification of Hematopoietic Cell – Stromal Cell Interactions in Histological Images of Undecalcified Bone

Automated Quantification of Hematopoietic Cell – Stromal Cell Interactions in Histological Images of Undecalcified Bone

Published on: April 8, 2015

Flow Cytometry Analysis of Murine Bone Marrow Hematopoietic Stem and Progenitor Cells and Stromal Niche Cells

Flow Cytometry Analysis of Murine Bone Marrow Hematopoietic Stem and Progenitor Cells and Stromal Niche Cells

Published on: September 28, 2022

Area of Science:

Biochemistry
Hematology
Neuroscience

Background:

Tachykinins, discovered in the 1930s, are peptides with diverse physiological roles.
Tachykinin receptor antagonists show therapeutic potential for neurodegenerative disorders, cardiovascular diseases, pain, and cancer.
Tachykinins significantly impact hematopoiesis, affecting endothelial and vascular conditions.

Purpose of the Study:

To review the regulatory network of cytokines and tachykinins in hematopoiesis.
To explore the role of tachykinins in normal hematopoietic functions.
To investigate the involvement of tachykinins in hematological disorders.

Main Methods:

Literature review of studies on tachykinins and hematopoiesis.
Analysis of the interplay between cytokines and tachykinins in regulating stem cell function.
Examination of tachykinin involvement in bone marrow disorders.

Main Results:

Tachykinins, alongside cytokines, form a critical network regulating hematopoiesis.
Hematopoiesis is dependent on specific bone marrow-resident hematopoietic stem cells.
Tachykinins influence endothelial tissue and vascular health through their effects on blood cell formation.

Conclusions:

Understanding tachykinin-cytokine interactions in hematopoiesis is crucial.
Insights into tachykinin function in hematological disorders can drive therapeutic innovation.
This knowledge may lead to novel treatments for bone marrow disorders, including fibrosis, leukemia, and anemia.