Related Experiment Video
Updated: Jul 13, 2026

Use of In vivo Imaging to Monitor the Progression of Experimental Mouse Cytomegalovirus Infection in Neonates
Published on: July 6, 2013
Emergence and persistence of multiple antiviral-resistant CMV strains in a highly immunocompromised child
Jenna M Iwasenko1, Gillian M Scott, John B Ziegler
1Virology Research, POWH and UNSW Research Laboratories, Prince of Wales Hospital, Randwick, NSW, Australia.
Background:
The emergence of human cytomegalovirus (CMV) antiviral resistance plays a significant role in disease progression in immunocompromised patients who have received antiviral therapy.
Objectives:
To determine the pattern of antiviral-resistant CMV strains in a highly immunocompromised child.
Study Design:
Retrospective specimens of blood and urine were analysed using PCR-sequencing to identify antiviral-resistant CMV strains containing UL97 or UL54 mutations.
Results:
CMV strains resistant to antiviral agents contributed to disease in a bone marrow transplant recipient with X-linked severe combined immunodeficiency (SCID) treated with ganciclovir (GCV) and foscarnet (FOS). Retrospective analyses detected GCV-resistant CMV (L595S) in a specimen taken after disease progression. This GCV-resistant CMV strain persisted for 1 year, after which time it was no longer detected even though the patient continued to receive GCV. A FOS-resistant strain (T700A) then emerged even though no FOS had been administered in the preceding year.
Conclusion:
The detection of antiviral-resistant CMV did not follow the patterns found in other patients tested for antiviral resistance, including emergence of a FOS-resistant strain in the absence of antiviral-selective pressure. These findings indicate the patient's underlying immunosuppressive condition should be considered for diagnosis and management of resistant CMV.
More Related Videos
11:18Expanding Cytotoxic T Lymphocytes from Umbilical Cord Blood that Target Cytomegalovirus, Epstein-Barr Virus, and Adenovirus
Published on: May 7, 2012
10:24Automated Cell Enrichment of Cytomegalovirus-specific T cells for Clinical Applications using the Cytokine-capture System
Published on: October 5, 2015
Related Concept Videos
Cytomegalovirus Disease
Cryptococcal Meningitis
Immunodeficiency Diseases
There are three main causes of immunodeficiency disorders...
Respiratory Syncytial Virus Disease
Pharmacokinetics in Pediatric Patients: Drug Excretion
Retrovirus Life Cycles