Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Macromolecule biosynthesis: a key function of sleep.

Miroslaw Mackiewicz1, Keith R Shockley, Micah A Romer

  • 1Center for Sleep and Respiratory Neurobiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-3403, USA. mirekmm@mail.med.upenn.edu

Physiological Genomics
|August 19, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Phenotype Refinement Influences GWAS-Implicated Variant Effect Sizes for Insomnia.

Journal of sleep research·2026
Same author

Generalizability of symptom-based subtypes of moderate to severe OSA patients within and between ethnic groups.

Annals of the American Thoracic Society·2026
Same author

COMPREHENSIVE GENETIC INVESTIGATION REVEALS HETEROGENEOUS PATHWAYS TO OBSTRUCTIVE SLEEP APNEA.

medRxiv : the preprint server for health sciences·2026
Same author

Cross-species evidence for a developmental origin of adult hypersomnia with loss of synaptic adhesion molecules beat-Ia/CADM2.

Nature communications·2026
Same author

Positive airway pressure therapy and cardiovascular events in obstructive sleep apnoea: an observational clinical cohort study.

Sleep medicine·2025
Same author

Respiratory Inductance Plethysmography to Quantify Changes in Ventilation in Obstructive Sleep Apnea.

IEEE transactions on bio-medical engineering·2025

Sleep is vital for cellular repair. This study reveals sleep significantly alters gene expression in mouse brains, promoting biosynthesis and rebuilding cellular components for wakefulness.

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Genetics

Background:

  • The fundamental biological functions of sleep remain largely unknown.
  • Understanding gene expression changes during sleep is crucial for deciphering its role.

Purpose of the Study:

  • To investigate alterations in gene expression within the mouse cerebral cortex and hypothalamus during sleep and sleep deprivation.
  • To identify genes with sleep-specific expression patterns and their functional categories.

Main Methods:

  • Analysis of gene expression in mouse cerebral cortex and hypothalamus.
  • Comparison of gene expression profiles during different sleep durations and periods of sleep deprivation.

Main Results:

  • Significant differences in gene expression were observed between sleep and sleep deprivation states, with thousands of genes showing altered patterns.

Related Experiment Videos

  • Numerous genes were identified as sleep-specific, with notable upregulation in pathways related to biosynthesis, cholesterol synthesis, lipid transport, protein synthesis, and antioxidant defense.
  • Specific upregulation of genes involved in energy regulation and vesicle maintenance was observed during sleep in both brain regions.

    • Conclusions:

    • Sleep actively promotes the rebuilding of essential cellular components in the brain.
    • The observed gene expression changes suggest sleep prepares the organism for subsequent wakefulness by restoring cellular functions.