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Updated: Jul 13, 2026

Comprehensive & Cost Effective Laboratory Monitoring of HIV/AIDS: an African Role Model
Published on: October 31, 2010
Evaluation of change in CD4+ cell counts in AIDS clinical trials
1Department of Biostatistics and Computational Biology, University of Rochester Medical Center, Rochester, NY 14642, USA. hliang@bst.rochester.edu
Abstract:
To evaluate the antiretroviral activity of antiretroviral agents and to compare the effects of two different antiretroviral agents, we propose a non-parametric mixed-effects model to investigate change of CD4+ counts. The proposed model and methods are applied to analyse the data from PACTG345 study. Population and individual patterns of change of CD4+ counts and a reference band are obtained. Our results indicate that treatment with high-dose ritonavir is significantly superior compared with low-dose ritonavir.

