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Updated: May 5, 2026
07:29
Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
Published on: October 12, 2017
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High-density lipoprotein as a therapeutic target: a systematic review
Inder M Singh1, Mehdi H Shishehbor, Benjamin J Ansell
1Department of Cardiovascular Medicine, Krannert Institute of Cardiology, Indiana University Medical Center, Indianapolis, USA. shishem@gmail.com
JAMA
|August 21, 2007
Summary
Current strategies can raise high-density lipoprotein cholesterol (HDL-C) by 20-30%, but evidence for cardiovascular benefit independent of other lipids remains limited. Further trials are needed to explore HDL-C modification for cardiovascular disease prevention.
Area of Science:
- Cardiovascular Medicine
- Lipid Metabolism
- Pharmacology
Background:
- High-density lipoprotein cholesterol (HDL-C) is a key cardiovascular risk factor and a growing therapeutic target.
- Understanding HDL-C metabolism is crucial for developing effective cardiovascular disease (CVD) prevention strategies.
Purpose of the Study:
- To review current and emerging strategies for modifying high-density lipoproteins (HDLs).
- To evaluate the evidence supporting HDL-C modification for cardiovascular outcomes.
Main Methods:
- Systematic literature search (1965-May 2007) in MEDLINE and Cochrane databases.
- Prioritized randomized controlled trials, meta-analyses, and mechanistic studies.
- Included review of major cardiovascular meeting presentations and ongoing clinical trials.
Main Results:
- 31 randomized controlled trials met inclusion criteria.
- Optimized current strategies increase HDL-C by 20-30%.
- Proof of cardiovascular outcome reduction independent of LDL-C or triglycerides is elusive; novel agents show variable effects on HDL-C.
Conclusions:
- Modest evidence supports aggressive HDL-C elevation beyond lifestyle modification.
- Ongoing trials targeting HDL metabolism pathways may offer new cardiovascular treatment options.
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