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Interstitial lung disease in infancy

S Balasubramanian1, Lalitha Janakiraman, R Ganesh

  • 1Kanchi Kamakoti CHILDS Trust Hospital, 12-A, Nageswara road, Nungambakkam, Chennai-600 034, India. sbsped53@sify.com

Indian Journal of Pediatrics
|August 19, 2007
PubMed

Insights

Cytomegalovirus (CMV) infection is the most frequent cause of infantile interstitial lung disease (ILD). Further research is needed to understand the long-term outcomes for affected infants.

Area of Science:

  • Pediatric Pulmonology
  • Infectious Diseases
  • Radiology

Background:

  • Interstitial lung disease (ILD) in infancy presents a diagnostic challenge.
  • Understanding the etiology and clinical features is crucial for timely intervention.

Purpose of the Study:

  • To delineate the clinical profile of infants diagnosed with interstitial lung disease.
  • To identify common causes and radiographic findings of ILD in this age group.

Main Methods:

  • Retrospective analysis of 9 infants (1 month to 1 year) with ILD.
  • Inclusion criteria: prolonged respiratory symptoms, diffuse chest radiography infiltrates, hypoxemia, and HRCT findings.
  • Case record review for clinical data, treatment, and outcomes.

Main Results:

  • Tachypnea, cough, and hypoxia were universal findings.
  • Cytomegalovirus (CMV) infection was identified in 56% of cases.
  • Reticulo-nodular patterns on radiography and interstitial infiltrates on HRCT were common.

Conclusions:

  • CMV infection is the predominant cause of infantile ILD in this cohort.
  • Long-term follow-up data are essential to fully understand the disease's impact.
Abstract

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