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Updated: Jul 13, 2026

Identification of Transcription Factor Regulators using Medium-Throughput Screening of Arrayed Libraries and a Dual-Luciferase-Based Reporter
11:32

Identification of Transcription Factor Regulators using Medium-Throughput Screening of Arrayed Libraries and a Dual-Luciferase-Based Reporter

Published on: March 27, 2020

P-TEFb is a crucial co-factor for Myc transactivation

Barbara Gargano1, Stefano Amente, Barbara Majello

  • 1Department of Structural and Functional Biology, University of Naples Federico II, Naples, Italy.

Cell Cycle (Georgetown, Tex.)
|August 19, 2007
PubMed

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Master Transcription Regulators

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Transcription Factors

Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
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