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Related Experiment Video

Updated: Jul 13, 2026

Phthalic Acid Ester-Binding DNA Aptamer Selection, Characterization, and Application to an Electrochemical Aptasensor
09:33

Phthalic Acid Ester-Binding DNA Aptamer Selection, Characterization, and Application to an Electrochemical Aptasensor

Published on: March 21, 2018

Aptamers as elements of bioelectronic devices.

Mònica Mir1, Ioanis Katakis

  • 1Bioengineering and Bioelectrochemistry Group, Departament d'Enginyeria Química, Universitat Rovira i Virgili, Tarragona, Spain. ioanis.katakis@urv.cat.

Molecular Biosystems
|August 19, 2007
PubMed
Summary

A novel biosensor uses a ferrocene-labeled aptamer and microperoxidase to detect stimuli. This reversible amperometric device offers real-time biomolecular sensing capabilities.

Area of Science:

  • Biomedical Engineering
  • Electrochemistry
  • Molecular Biology

Background:

  • Biosensors are crucial for real-time monitoring.
  • Developing sensitive and specific biomolecular detection systems remains a challenge.

Purpose of the Study:

  • To develop a novel amperometric biosensor.
  • To utilize a ferrocene-labeled aptamer and microperoxidase for enhanced detection.

Main Methods:

  • Co-immobilization of a ferrocene-labeled aptamer with microperoxidase.
  • Electrochemical analysis to demonstrate device functionality.
  • Testing the device's response to external stimuli.

Main Results:

  • Demonstrated a reversible amperometric biosensor.

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Last Updated: Jul 13, 2026

Phthalic Acid Ester-Binding DNA Aptamer Selection, Characterization, and Application to an Electrochemical Aptasensor
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  • The device showed real-time responsiveness to stimuli.
  • Successful integration of aptamer and enzyme for redox signaling.

    • Conclusions:

    • The developed biosensor shows promise for real-time biomolecular detection.
    • Ferrocene-aptamer conjugates can act as effective redox partners for enzymes.
    • This approach enables the creation of advanced amperometric biomolecular devices.