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Related Concept Videos

Parkinson's Disease: Overview01:15

Parkinson's Disease: Overview

Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is to...
Parkinson Disease ll: Pathophysiology01:24

Parkinson Disease ll: Pathophysiology

Parkinson disease (PD) is a progressive neurodegenerative disorder primarily affecting movement, with additional non-motor features. Its pathophysiology involves complex interactions among genetic susceptibility, environmental exposures, and cellular dysfunction, including dopaminergic neuron loss, protein aggregation, and mitochondrial impairment.Selective NeurodegenerationA key feature is the degeneration of dopaminergic neurons in the substantia nigra pars compacta, leading to reduced...
Alterations in Muscle Tone ll01:12

Alterations in Muscle Tone ll

Alterations in muscle tone are common manifestations of neurological disorders and reflect dysfunction within different nervous system regions. Spasticity, paratonia, and dystonia represent distinct forms of hypertonia, each with unique mechanisms, clinical features, and diagnostic importance.CharacteristicsSpasticity happens from upper motor neuron lesions and is characterized by velocity-dependent resistance to passive movement. Clinical features include:Exaggerated deep tendon reflexesClonus...
Myasthenia Gravis: Overview and Treatment01:20

Myasthenia Gravis: Overview and Treatment

Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which leads...
Parkinson's Disease: Treatment01:24

Parkinson's Disease: Treatment

Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of its...
Cholinergic Antagonists: Therapeutic Uses01:26

Cholinergic Antagonists: Therapeutic Uses

Antimuscarinic drugs have various therapeutic applications by inhibiting parasympathetic stimulation in different systems. Here are the key therapeutic uses of antimuscarinics:    
Respiratory Tract: Ipratropium, aclidinium, and tiotropium treat asthma, chronic bronchitis, and chronic obstructive pulmonary disease (COPD). They protect against bronchoconstriction caused by irritants like cigarette smoke, sulfur dioxide, and ozone. They also help reduce nasopharyngeal secretions in common...

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Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

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Same author

White matter predicts functional connectivity in premanifest Huntington's disease.

Annals of clinical and translational neurology·2017
Same author

[German consortium for frontotemporal lobar degeneration].

Der Nervenarzt·2011
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[The presymptomatic stage of neurodegenerative disorders].

Der Nervenarzt·2011
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[Treatment of mental disorders in patients with Parkinson's disease].

Fortschritte der Neurologie-Psychiatrie·2010
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The human premotor oculomotor brainstem system - can it help to understand oculomotor symptoms in Huntington's disease?

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Eye-head coordination in moderately affected Huntington's Disease patients: do head movements facilitate gaze shifts?

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Related Experiment Video

Updated: Jul 13, 2026

Rating L-DOPA-Induced Dyskinesias in the Unilaterally 6-OHDA-Lesioned Rat Model of Parkinson's Disease
06:45

Rating L-DOPA-Induced Dyskinesias in the Unilaterally 6-OHDA-Lesioned Rat Model of Parkinson's Disease

Published on: October 4, 2021

[Chorea. Causes, diagnosis, and therapy].

C M Kosinski1, B Landwehrmeyer

  • 1Neurologische Klinik, Universitätsklinikum, Pauwelsstrasse 30, 52074, Aachen, Germany. CKosinski@ukaachen.de

Der Nervenarzt
|August 19, 2007
PubMed
Summary

Diagnosing chorea involves identifying rare diseases, with Huntington's disease being the most common hereditary cause. Genetic testing confirms diagnosis, but effective treatments remain limited, necessitating research networks for improved patient care.

Area of Science:

  • Neurology
  • Genetics
  • Rare Diseases

Context:

  • Chorea diagnosis presents challenges due to numerous rare underlying conditions.
  • Huntington's disease is the predominant cause of hereditary chorea.
  • Current treatment options for chorea are limited and often associated with significant side effects.

Purpose:

  • To provide clinical and laboratory diagnostic clues for differentiating chorea causes.
  • To discuss the genetic confirmation and implications of predictive testing for Huntington's disease.
  • To highlight the unmet need for disease-modifying therapies and the role of research networks.

Summary:

  • This review outlines differential diagnoses for chorea, emphasizing clinical and laboratory findings.
  • It details Huntington's disease, including its genetic basis, variable disease courses, and diagnostic confirmation.

Related Experiment Videos

Last Updated: Jul 13, 2026

Rating L-DOPA-Induced Dyskinesias in the Unilaterally 6-OHDA-Lesioned Rat Model of Parkinson's Disease
06:45

Rating L-DOPA-Induced Dyskinesias in the Unilaterally 6-OHDA-Lesioned Rat Model of Parkinson's Disease

Published on: October 4, 2021

  • The limited therapeutic landscape and the establishment of the European Huntington's Disease Network for advancing clinical studies are discussed.

    • Impact:

    • Aids clinicians in diagnosing complex chorea cases by suggesting relevant investigations.
    • Informs patients and healthcare providers about the genetic aspects and predictive testing for Huntington's disease.
    • Underscores the critical need for developing novel therapeutic strategies and collaborative research efforts.