Related Experiment Video
Updated: Jul 13, 2026

Assessing Antibody-dependent, Cell-mediated Cytotoxicity in Cancer Cells using Antibody-Dependent Cell-Mediated Cytotoxicity Reporter Bioassay
Published on: September 13, 2024
The anti-cancer effects of quinolone antibiotics?
M Paul1, A Gafter-Gvili, A Fraser
1Department of Medicine E and Infectious Diseases Unit, Rabin Medical Center, Beilinson Hospital, Petah-Tikva, 49100, Israel. pil1pel@zahav.net.il
Abstract:
A previous meta-analysis showed that quinolones administered for prophylaxis of infections among cancer patients reduced all-cause mortality. We extracted from the primary trials infection-related and all-cause mortality as reported and assessed the effect of quinolones on non-infection-related mortality through meta-analysis. Among trials comparing quinolones to placebo or no treatment, a significant reduction in non-infection-related mortality was observed (relative risk 0.54, 95% confidence interval 0.32-0.93, 15 trials, 3,320 patients). This finding might represent biased attribution of deaths to infection or might be compatible with an anti-cancer effect of quinolone antibiotics. We present further analyses addressing these possibilities.
Related Concept Videos
Inhibitors of Bacterial DNA Synthesis
Cancer Therapies
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Gene Regulation in Microbial Communities: Quorum Sensing
Targeted Cancer Therapies
There are several types of targeted therapies against specific...
Inhibitors of Bacterial Protein Synthesis
Clinical Significance of Antibiotic Resistance

