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Related Experiment Video

Updated: Jul 13, 2026

Mouse Cardiac Arrest Model for Brain Imaging and Brain Physiology Monitoring During Ischemia and Resuscitation

Mouse Cardiac Arrest Model for Brain Imaging and Brain Physiology Monitoring During Ischemia and Resuscitation

Published on: April 14, 2023

Cardiovascular collapse associated with beta blockade in thyroid storm.

R Dalan¹, Melvin K Leow, Melvin C Leow

¹Department of Endocrinology, Tan Tock Seng Hospital, Singapore. rinkoo99@yahoo.com

Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [And] German Diabetes Association

|August 19, 2007

Summary

This summary is machine-generated.

Oral propranolol use in thyroid storm patients with low cardiac output may precipitate cardiorespiratory arrest. Consider ultra-short-acting beta-blockers like esmolol cautiously as a safer alternative.

Related Experiment Videos

Last Updated: Jul 13, 2026

Mouse Cardiac Arrest Model for Brain Imaging and Brain Physiology Monitoring During Ischemia and Resuscitation

Mouse Cardiac Arrest Model for Brain Imaging and Brain Physiology Monitoring During Ischemia and Resuscitation

Published on: April 14, 2023

Area of Science:

Cardiology
Endocrinology
Pharmacology

Background:

Thyroid storm is a life-threatening condition characterized by exaggerated hyperthyroid symptoms.
Management often involves beta-blockers to control adrenergic symptoms.

Observation:

Three cases of thyroid storm patients experienced sudden cardiorespiratory arrest shortly after oral propranolol administration.
These events occurred within hours to 12 hours of initiating propranolol therapy.

Findings:

Oral propranolol may pose a risk for cardiorespiratory arrest in select thyroid storm patients, particularly those with low-output cardiac failure.
The timing of arrest suggests a potential adverse reaction to oral beta-blocker therapy in this critical state.

Implications:

Clinicians should exercise caution when prescribing oral propranolol to thyroid storm patients with compromised cardiac function.
Intravenous esmolol, an ultra-short-acting beta-blocker, may be a safer alternative when beta-blockade is necessary, with careful monitoring.