Short/long heterozygotes at 5HTTLPR and white matter lesions in geriatric depression
David C Steffens1, Warren D Taylor, Douglas R McQuoid
1Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA. steff001@mc.duke.edu
Objective:
We examined the relationship between 5HTTLPR genotype and volume of magnetic resonance imaging (MRI) brain lesions.
Method:
We studied 217 older depressed patients and 141 individuals in the comparison group using a standard brain MRI protocol to calculate lesion volumes. Genotype at 5HTTLPR was determined for each subject.
Results:
In age-adjusted models, the l/s genotype was associated with increased volume of total and white-matter lesions among depressed patients. This relationship lost significance in models controlling for reported hypertension.
Conclusions:
The finding that 5HTTLPR heterozygotes have higher vascular lesion volumes may be related to development of hypertension.
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