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A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats
Published on: May 22, 2019
Depression or apathy and functional recovery after stroke
Seiji Hama1, Hidehisa Yamashita, Masaya Shigenobu
1Department of Rehabilitation, Nishi-Hiroshima Rehabilitation Hospital, Hiroshima, Japan. wel@welnet.jp
International Journal of Geriatric Psychiatry
|August 19, 2007
Summary
Apathy, not depression, significantly impacts functional recovery after stroke. Understanding apathy
Area of Science:
- Neuroscience
- Psychiatry
- Rehabilitation Medicine
Background:
- Depression and apathy are common post-stroke conditions.
- Limited research has explored their respective influences on functional outcomes.
Purpose of the Study:
- To investigate the independent effects of post-stroke depression and apathy on functional recovery.
- To analyze the relationship between these psychological symptoms and physical disability in stroke survivors.
Main Methods:
- Assessed depression using Zung Self-Rating Depression Scale (SDS) and apathy using Apathy Scale (AS).
- Utilized Neuropsychiatric Inventory (NPI) for observer ratings and Functional Independence Measurement (FIM) for physical disability.
- Employed post-hoc tests and multiple regression analysis to determine independent effects.
Main Results:
- Apathy scores (AS) and cognitive function (MMSE) negatively correlated with functional improvement (FIM).
- Depression scores (SDS) did not show a significant correlation with functional recovery.
- Prevalence rates for depression and apathy varied between self- and observer-rated scales.
Conclusions:
- Apathy appears more strongly associated with functional abilities post-stroke than depression.
- Apathy may play a more significant role in interacting with the stroke recovery process.
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