Related Experiment Videos
HTR2C haplotypes and antipsychotics-induced weight gain: X-linked multimarker analysis
Vincenzo De Luca1, Daniel J Müller, Rudi Hwang
1Department of Psychiatry, Centre for Addiction and Mental Health, Neurogenetics Section, University of Toronto, Toronto, ON, Canada. Vincenzo_Deluca@camh.net
Human Psychopharmacology
|August 19, 2007
Summary
This study investigated the serotonin 5-HT2C receptor (HTR2C) gene polymorphisms and their link to antipsychotic-induced weight gain in schizophrenia patients. No significant genetic risk was found, suggesting other factors influence weight changes during treatment.
Area of Science:
- Pharmacogenetics
- Neuroscience
- Psychiatry
Background:
- The serotonin 5-HT2C receptor (HTR2C) is implicated in feeding behavior and obesity.
- Antipsychotics (AP) with HTR2C antagonism can cause weight gain in some individuals.
- Previous studies identified associations with HTR2C polymorphisms, but haplotype analyses are lacking.
Purpose of the Study:
- To investigate the association between HTR2C gene functional polymorphisms and antipsychotic-induced weight gain.
- To perform haplotype analyses for Cys23Ser and -759C/T polymorphisms in schizophrenic patients treated with clozapine.
Main Methods:
- Analyzed three HTR2C functional polymorphisms (Cys23Ser, -759C/T, and (GT)12-18/(CT)4-5) in 139 schizophrenic patients.
- Assessed weight gain over 6-14 weeks in patients treated primarily with clozapine.
- Conducted single marker and haplotype analyses, accounting for X-linked heterogeneity and confounding factors.
Main Results:
- No significant associations were found between single HTR2C markers or haplotypes and antipsychotic-induced weight gain.
- A potential protective effect of the Long-C-Ser haplotype was observed, but with a small sample size.
- The study did not detect significant genetic risk conferred by the analyzed HTR2C polymorphisms.
Conclusions:
- This pilot study did not identify specific HTR2C haplotypes that confer risk for antipsychotic-induced weight gain.
- The findings suggest that other genetic or environmental factors may play a more significant role in weight gain.
- Further research with larger cohorts is needed to fully elucidate the role of HTR2C in treatment-emergent weight gain.
Related Concept Videos
01:29Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu
Genetic variations significantly influence drug response through pharmacokinetics, receptor interactions, and biologic milieu modifications. Pharmacokinetic alterations impact drug metabolism and clearance, affecting efficacy and toxicity. Variants in drug-metabolizing enzymes, such as CYP2C9 and CYP2C19, alter drug activation and elimination. For example, CYP2C9 loss-of-function variants require lower warfarin doses to prevent excessive bleeding, while CYP2C19 variants reduce clopidogrel...
01:11Genome-wide Association Studies-GWAS
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
01:28Human Genetics
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
The complex relationship between genetics and psychology is observable through common biological components such...
01:11Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase
Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...
01:29Pharmacogenomics: Identification of New Drug Targets
Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
01:23Antidepressant Drugs: MAOIs and Other Agents
Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...