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Quantitative Mass Spectrometric Profiling of Cancer-cell Proteomes Derived From Liquid and Solid Tumors
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[Interaction between anticancer drugs and DNA studied by using electrospray ionization mass spectrometry]

Jin-Fa Bai1, Zhi-Qiang Liu, Zeper Abliz

  • 1Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China.

Yao Xue Xue Bao = Acta Pharmaceutica Sinica
|August 19, 2007
PubMed
Summary

Anticancer drugs distamycin A (DM) and netropsin (NP) bind DNA minor grooves, with DM preferring AT-rich DNA and NP binding strongly to sequences with 4 A/T bases. Mitoxantrone (MT) intercalates GC-rich DNA.

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