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Adjuvant Activity of Mycobacterium paratuberculosis in Enhancing the Immunogenicity of Autoantigens During Experimental Autoimmune Encephalomyelitis
Published on: May 12, 2023
[Mycobacterium avium subsp. paratuberculosis in inflammatory bowel diseases]
Andrzej Szkaradkiewicz1, Izabela Chudzicka-Strugała, Barbara Zwoździak
1Katedra i Zakład Mikrobiologii Lekarskiej AM w Poznaniu. szkaradkiewicza@poczta.onet.pl
Mycobacterium avium subsp. paratuberculosis infection was detected in patients with Leśniowski-Crohn disease and ulcerative colitis. The findings suggest this bacterium plays a role in the development of Leśniowski-Crohn disease.
Area of Science:
- Microbiology
- Gastroenterology
- Immunology
Context:
- Inflammatory bowel disease (IBD) encompasses Leśniowski-Crohn disease (LCD) and ulcerative colitis (UC).
- The etiopathogenesis of LCD and UC remains incompletely understood, with infectious agents being investigated as potential triggers.
- Mycobacterium avium subsp. paratuberculosis (MAP) has been implicated in LCD.
Purpose:
- To investigate the presence of MAP DNA in intestinal tissues of patients with LCD and UC compared to healthy controls.
- To determine the prevalence of MAP infection in these patient groups.
Summary:
- DNA was extracted from intestinal tissue samples of 16 LCD patients, 20 UC patients, and 12 healthy controls.
- Polymerase Chain Reaction-Enzyme Linked Immunosorbent Assay (PCR-ELISA) was used to detect MAP DNA.
- MAP DNA was identified in 62.5% of LCD patients, 25% of UC patients, and 8.3% of controls.
Impact:
- The study provides evidence suggesting MAP involvement in the etiopathogenesis of Leśniowski-Crohn disease.
- These findings may open new avenues for diagnostic and therapeutic strategies targeting MAP in LCD.
- Further research is warranted to elucidate the precise mechanisms of MAP in IBD.
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