Related Experiment Videos

Treatment of orthopedic infections caused by resistant staphylococci

D Jahoda1, O Nyc, D Pokorný

  • 11st Orthopedic Clinic, 1st Medical Faculty, Charles University, 150 06 Prague, Czechia. david.jahoda@post.cz

Folia Microbiologica
|August 19, 2007
PubMed

Insights

Linezolid effectively treated locomotion apparatus infections, including osteomyelitis and endoprosthesis infections, with an 86.6% success rate. This antibiotic is a valuable reserve for challenging Gram-positive infections when other options fail.

Area of Science:

  • Infectious Diseases
  • Orthopedic Surgery
  • Pharmacology

Background:

  • Locomotion apparatus infections pose significant treatment challenges.
  • Multiresistant Gram-positive bacteria, including MRSA, are a growing concern.
  • Limited treatment options exist for patients with allergies or intolerance to standard antibiotics.

Purpose of the Study:

  • To evaluate the efficacy and safety of linezolid in treating infections of the locomotion apparatus.
  • To assess linezolid's role as a reserve antibiotic for complex Gram-positive infections.

Main Methods:

  • Retrospective analysis of 15 patients treated with linezolid between 1999-2005.
  • Combined antibiotic therapy with surgical intervention in most cases.
  • Microbiological methods included Mueller-Hinton agar, oxacillin, cephoxitin disk diffusion, and E-test for linezolid sensitivity.

Main Results:

  • A success rate of 86.6% was achieved in treating diverse locomotion apparatus infections.
  • Average linezolid treatment duration was 26 days (10 IV, 16 oral).
  • No undesirable side effects were reported during linezolid administration.

Conclusions:

  • Linezolid demonstrates high efficacy and safety for treating challenging Gram-positive infections of the musculoskeletal system.
  • It serves as a crucial medical reserve antibiotic for patients with limited treatment alternatives.
  • Linezolid is a valuable option in emergencies or when other effective antibiotics are contraindicated.

Related Concept Videos

Clinical Significance of Antibiotic Resistance01:25

Clinical Significance of Antibiotic Resistance

Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...
Mechanism of Antibiotic Resistance in MRSA01:25

Mechanism of Antibiotic Resistance in MRSA

Antibiotic resistance in bacteria arises when microorganisms evolve the ability to withstand drugs designed to kill them or inhibit their growth, rendering once-effective treatments useless. This phenomenon, driven by genetic change and selection under antibiotic exposure, poses a profound threat to modern medicine. Mechanisms include drug-inactivating enzymes (e.g., β-lactamases), efflux pumps that eject antibiotics, mutations altering antibiotic targets, decreased drug uptake, and acquisition...
Acute Pyelonephritis II: Diagnostic Studies and Management01:28

Acute Pyelonephritis II: Diagnostic Studies and Management

Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care01:30

Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care

A healthcare provider can diagnose a urinary tract infection (UTI) through several methods:Medical History and Symptoms: The provider will take a detailed medical history and ask about symptoms such as frequent urination, burning sensation during urination, and lower abdominal pain.Urinalysis: A clean-catch urine sample is collected in a sterile container and tested for the presence of bacteria, white blood cells (leukocytes), nitrites, blood, and protein. The presence of leukocytes and...
Development of Antibiotic Resistance01:30

Development of Antibiotic Resistance

Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...