Related Experiment Video
Updated: Jul 13, 2026
08:03
Cervical Lymph Duct-Cannulated Rat Model for Assessing Lymphatic Transport from the Head and Brain
Published on: March 10, 2026
Intravascular large B-cell lymphoma presenting with neurological syndromes: clinicopathologic study
A Ortega Aznar1, M A Montero, R Rovira
1Department of Pathology (Neuropathology), Vail d'Hebron University Hospital, Barcelona, Spain. aortega@vhebron.net
Clinical Neuropathology
|August 19, 2007
Summary
Intravascular lymphoma (IVL) is a rare cancer causing tumors within blood vessels, often affecting the nervous system. Early diagnosis is challenging, frequently requiring autopsy for confirmation.
Area of Science:
- Hematology
- Neurology
- Oncology
Background:
- Intravascular lymphoma (IVL) is an uncommon extranodal lymphoma characterized by exclusive intravascular tumor growth.
- The nervous system is particularly susceptible, with 1/3 of cases presenting with neurological involvement at onset and 2/3 developing symptoms during the disease course.
Observation:
- IVL can manifest as diverse central and peripheral nervous system syndromes, sometimes multiple in a single patient.
- Diagnostic challenges arise from varied clinical presentations and low specificity of neurological tests, often leading to diagnosis at autopsy.
- This case details an immunocompetent patient with IVL presenting with cauda equina syndrome and progressive neurological manifestations.
Findings:
- Spinal cord biopsy in life was inconclusive due to lack of neoplastic involvement in examined vessels.
- Immunohistochemistry confirmed a large B-cell lymphoma.
- The study reviews neurological features of IVL from previously published cases.
Implications:
- Highlights the diagnostic difficulties of IVL, particularly its neurological manifestations.
- Emphasizes the need for increased clinical suspicion and potentially advanced diagnostic techniques for early IVL detection.
- Underscores the importance of neuropathological examination in diagnosing challenging cases of intravascular lymphoma.
Related Concept Videos
01:26Encephalitis ll: Pathophysiology
Encephalitis is inflammation of the brain parenchyma caused by direct viral invasion or immune-mediated mechanisms triggered by infections or tumors. Both processes lead to neuronal injury, disrupted neurotransmission, and diverse neurological symptoms, often with overlapping clinical and pathological features.Autoimmune EncephalitisIn autoimmune encephalitis, antibodies target neuronal antigens on cell surfaces, synapses, or within neurons. A key example is anti-NMDAR encephalitis, which can...
01:21Aneurysm II: Clinical Manifestations and Diagnostic Studies
Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
01:19Encephalitis l: Introduction
Encephalitis is inflammation of the brain parenchyma, most often due to infections or autoimmune processes. It presents with neuropsychiatric features such as fever, altered mental status, behavioral changes, cognitive dysfunction, seizures, focal deficits, and sometimes autonomic instability. In some cases, the meninges are also involved, resulting in meningoencephalitis.Infectious CausesInfectious encephalitis is most commonly viral but can also result from bacterial, fungal, or parasitic...
01:19Multiple Sclerosis l: Introduction
Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...