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Complementary Use of Microscopic Techniques and Fluorescence Reading in Studying Cryptococcus-Amoeba Interactions
Published on: June 22, 2019
Crosstalk at the initial encounter: interplay between host defense and ameba survival strategies
Xiaoti Guo1, Eric Houpt, William A Petri
1Division of Infectious Diseases and International Health, University of Virginia, Charlottesville, VA 22908-1340, USA.
Abstract:
The host-parasite relationship is based on a series of interplays between host defense mechanisms and parasite survival strategies. Progress has been made in understanding the role of host immune response in amebiasis. While host cells elaborate diverse mechanisms for pathogen expulsion, amebae have also developed complex strategies to modulate host immune response and facilitate their own survival. This paper will give an overview of current research on the mutual interactions between host and Entamoeba histolytica in human and experimental amebiasis. Understanding this crosstalk is crucial for the effective design and implementation of new vaccines and drugs for this leading parasitic disease.
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