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Structural insights into the clathrin coat.

Anna Young1

  • 1Department of Biological Sciences, University of Warwick, Coventry CV4 7AL, West Midlands, UK. Anna.young@warwick.ac.uk

Seminars in Cell & Developmental Biology
|August 19, 2007
PubMed
Summary
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Clathrin, a protein involved in endocytosis, also plays roles in mitosis, including chromosome segregation and Golgi reassembly. Recent structural biology advances reveal intricate clathrin lattice interactions crucial for cellular functions.

Area of Science:

  • Cell Biology
  • Structural Biology
  • Molecular Biology

Background:

  • Clathrin is a cytoplasmic protein primarily known for its role in endocytosis and intracellular trafficking.
  • Emerging evidence highlights clathrin's involvement in mitosis, specifically chromosome segregation and Golgi apparatus reassembly.

Purpose of the Study:

  • To review the diverse cellular roles of clathrin beyond endocytosis.
  • To summarize recent structural biology advancements enhancing the understanding of clathrin assembly and interactions.

Main Methods:

  • Review of existing literature.
  • Integration of data from X-ray crystallography, NMR, and cryo-electron microscopy.
  • Analysis of clathrin structure and its interactions with binding partners.

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Main Results:

  • Clathrin functions as a heterohexamer forming a lattice structure.
  • Structural studies have elucidated clathrin-clathrin and clathrin-protein interactions within vesicles.
  • Clathrin's role in mitosis is increasingly recognized.

Conclusions:

  • Clathrin exhibits diverse functions within the cell, extending beyond endocytosis.
  • Structural biology techniques have significantly advanced our comprehension of clathrin's molecular mechanisms and interactions.