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Updated: Jul 13, 2026

Oncogene Expression Analysis with Alterations in pH in a Pancreatic Ductal Cell Line
Published on: April 11, 2025
Pancreatic acinar cell carcinoma with excessive alpha-fetoprotein expression
P Kolb-van Harten1, U Rosien, G Klöppel
1Department of Internal Medicine, Israelitic Hospital, University of Hamburg Academic Hospital, Hamburg, Germany.
Abstract:
We report a case of acinar cell carcinoma of the pancreas associated with excessively elevated levels of serum alpha-fetoprotein (>32,000 ng/ml). Abdominal computed tomography scan revealed a large pancreatic mass with infiltration of the splenic artery. Because of inoperability, palliative combination chemotherapy with gemcitabine and mitomycin C was administered. This regimen was associated with clinical improvement and dramatic decreases in both tumor size and serum alpha-fetoprotein. However, the patient died 7 months later from acute severe cardiac failure.
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