Related Experiment Video
Updated: Jul 13, 2026
05:53
Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
Published on: June 21, 2018
Skin testing correlates negatively with high-activity ACP1 *B/*C genotype
1Department of Internal Medicine, School of Medicine, University of Rome Tor Vergata, Rome, Italy.
International Archives of Allergy and Immunology
|August 19, 2007
Summary
The acid phosphatase locus 1 (ACP1) B/C genotype, associated with high enzyme activity, shows a protective effect against allergic manifestations. Lower prevalence of this genotype was observed in individuals with intense allergic skin reactions.
Area of Science:
- Immunogenetics
- Molecular Biology
- Allergy Research
Background:
- Acid phosphatase locus 1 (ACP1) is a polymorphic phosphotyrosine phosphatase.
- ACP1 interacts with IL4-RA and influences T cell receptor signaling.
- Prior research indicated a negative link between ACP1 *B/*C genotype and total IgE levels.
Purpose of the Study:
- To investigate the association between the high-activity ACP1 *B/*C genotype and allergic skin test responses.
- To determine if ACP1 genotype influences the intensity of allergic reactions.
Main Methods:
- Studied 300 adult subjects with allergic manifestations.
- Determined ACP1 genotypes using DNA analysis.
- Assessed the relationship between the *B/*C genotype and skin test reaction intensity.
Main Results:
- A significant negative correlation was found between skin test reaction intensity and the *B/*C genotype (p = 0.01).
- The *B/*C genotype was less frequent in allergic subjects with intense skin reactions compared to those with moderate reactions and healthy controls.
Conclusions:
- This study confirms the link between ACP1 polymorphism and allergic conditions.
- High ACP1 activity, indicated by the *B/*C genotype, appears to confer protection against allergic manifestations.
