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Updated: Jul 13, 2026
03:43
Oromucosal as an Alternative Method for Administration of Cannabis Products in Rodents
Published on: August 22, 2025
Cannabis; adverse effects from an oromucosal spray
1Department of Oral Medicine, UCL Eastman Dental Institute, 256 Gray's Inn Road, London, WC1X 8LD. c.scully@eastman.ucl.ac.uk
British Dental Journal
|August 19, 2007
Summary
Oromucosal cannabis spray for multiple sclerosis (MS) pain relief can cause oral burning and white lesions, likely due to its high alcohol content. Discontinuation of the spray may resolve these side effects.
Area of Science:
- Pharmacology
- Oral Medicine
- Neurology
Background:
- Oromucosal cannabis spray containing THC and CBD is used for multiple sclerosis (MS) pain.
- Some patients report oral burning, stinging, or white lesions, possibly burns.
Purpose of the Study:
- To investigate oral side effects of oromucosal cannabis spray in MS patients.
Main Methods:
- Open observational study of nine MS patients using the spray.
- Oral examinations and symptom reporting.
- Patients with lesions advised to discontinue spray.
Main Results:
- Eight of nine patients reported stinging sensations.
- Four patients presented with visible white oral mucosal lesions, primarily on the floor of the mouth.
Conclusions:
- White lesions were likely burns, improving after spray discontinuation.
- High alcohol concentration in the spray raises concerns for chronic oral use.
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