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Nasal continuous positive airway pressure affects pre- and postprandial intestinal blood flow velocity in preterm

T Havranek1, C Madramootoo, J D Carver

  • 1Division of Neonatology, Department of Pediatrics, University of South Florida College of Medicine, Tampa, FL, USA. thavrane@slu.edu

Journal of Perinatology : Official Journal of the California Perinatal Association
|August 19, 2007
PubMed

Insights

Nasal continuous positive airway pressure (CPAP) reduced intestinal blood flow velocities during enteral feedings in infants. This finding suggests CPAP may affect how well infants tolerate tube feeding.

Area of Science:

  • Neonatal physiology
  • Gastrointestinal blood flow
  • Respiratory support

Background:

  • Infants often require respiratory support like nasal continuous positive airway pressure (CPAP).
  • The impact of CPAP on gastrointestinal circulation and feeding tolerance in neonates is not fully understood.

Purpose of the Study:

  • To investigate the effect of nasal CPAP on intestinal blood flow velocity.
  • To assess changes in intestinal blood flow in response to enteral feedings with and without CPAP.
  • To evaluate the impact of CPAP on left ventricular output (LVO).

Main Methods:

  • Eighteen infants (birth weight 1793+/-350 g, gestational age 32.1+/-1.1 weeks) were studied.
  • Intestinal blood flow velocities (mean velocity, peak systolic velocity, end diastolic velocity) and left ventricular output were measured.
  • Measurements were taken during enteral feedings both on and off CPAP.

Main Results:

  • Mean velocity and peak systolic velocity of intestinal blood flow were significantly lower when infants received CPAP.
  • The timing of maximal blood flow velocity response to feeding was delayed when CPAP was discontinued.
  • Preprandial left ventricular output remained similar before and after CPAP discontinuation.

Conclusions:

  • Nasal CPAP influences pre- and postprandial intestinal blood flow velocity in infants.
  • These alterations in intestinal blood flow may have implications for enteral feeding tolerance in neonates receiving CPAP.
Abstract

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