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Enteric Bacterial Invasion Of Intestinal Epithelial Cells In Vitro Is Dramatically Enhanced Using a Vertical Diffusion Chamber Model
Published on: October 22, 2013
Campylobacter jejuni: molecular biology and pathogenesis
Kathryn T Young1, Lindsay M Davis, Victor J Dirita
1Department of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan 48109, USA.
Nature Reviews. Microbiology
|August 19, 2007
Summary
Campylobacter jejuni, a common foodborne pathogen, causes mild infections in chickens but severe enteritis in humans. Understanding differing host responses is key to studying its pathogenicity.
Area of Science:
- Microbiology
- Pathogen Biology
- Immunology
Background:
- Campylobacter jejuni is a prevalent foodborne bacterial pathogen.
- Its biology and pathogenicity are less understood compared to other pathogens.
- Recent advancements in model systems and technologies have increased research interest.
Purpose of the Study:
- To investigate the differential host responses to Campylobacter jejuni colonization.
- To enhance the understanding of C. jejuni's pathogenicity in various hosts.
Main Methods:
- Comparative analysis of host responses to C. jejuni.
- Utilizing model systems for infection studies.
Main Results:
- C. jejuni establishes persistent, benign infections in chickens.
- Laboratory mice rapidly clear C. jejuni infections.
- Humans experience significant inflammation and enteritis following C. jejuni infection.
Conclusions:
- Comparing host responses to C. jejuni colonization is crucial for understanding its pathogenicity.
- Differences in host immune responses contribute to varying disease outcomes.
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