A rapid method for the determination of cocaine in brain tissue
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Updated: Oct 9, 2026
Comprehensive Profiling of Dopamine Regulation in Substantia Nigra and Ventral Tegmental Area
Published on: August 10, 2012
S P Browne1, C M Moore, J Scheurer
1Department of Pharmacodynamics, University of Illinois, Chicago.
Abstract:
A rapid procedure is described for the extraction and analysis of brain samples for cocaine and benzoylecgonine. Human brain tissue was sectioned at autopsy, and samples were subjected to a lipase digestion, subsequent to solid-phase extraction. The distribution of cocaine and benzoylecgonine throughout different regions of the brain was determined by high-performance liquid chromatography.
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