Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Designing compound libraries targeting GPCRs.

E Jacoby1

  • 1Novartis Institutes for BioMedical Research, Discovery Tehnologies, Lichtstrasse 35, 4056 Basel, Switzerland. edgar.jacoby@novartis.com

Ernst Schering Foundation Symposium Proceedings
|August 21, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prevention of childhood obesity and food policies in Latin America: from research to practice.

Obesity reviews : an official journal of the International Association for the Study of Obesity·2017
Same author

Open PHACTS computational protocols for <i>in silico</i> target validation of cellular phenotypic screens: knowing the knowns.

MedChemComm·2016
Same author

The epidemic of childhood obesity in the Americas must be stopped: Governmental and PAHO leadership are crucial.

International journal of obesity supplements·2016
Same author

Chemogenomic strategies to expand the bioactive chemical space.

Current medicinal chemistry·2009
Same author

Ligand-specific scoring functions: improved ranking of docking solutions.

SAR and QSAR in environmental research·2008
Same author

New scoring functions for virtual screening from molecular dynamics simulations with a quantum-refined force-field (QRFF-MD). Application to cyclin-dependent kinase 2.

Journal of chemical information and modeling·2006
Same journal

Inhibiting Hdm2 and ubiquitin-activating enzyme: targeting the ubiquitin conjugating system in cancer.

Ernst Schering Foundation symposium proceedings·2009
Same journal

Dissecting roles of ubiquitination in the p53 pathway.

Ernst Schering Foundation symposium proceedings·2009
Same journal

Crosstalk between the SUMO and ubiquitin pathways.

Ernst Schering Foundation symposium proceedings·2009
Same journal

The ubiquitin system in health and disease. Preface.

Ernst Schering Foundation symposium proceedings·2009
Same journal

Approaches to discovering drugs that regulate E3 ubiquitin ligases.

Ernst Schering Foundation symposium proceedings·2009
Same journal

Regulation of T cell differentiation and allergic responses by the E3 ubiquitin ligase itch.

Ernst Schering Foundation symposium proceedings·2009
See all related articles

This study details strategies for designing compound libraries targeting G protein-coupled receptors (GPCRs), crucial for pharmaceutical research and drug discovery. We discuss recent approaches and their broader implications in GPCR drug development.

Area of Science:

  • Medicinal Chemistry
  • Pharmacology
  • Drug Discovery

Background:

  • G protein-coupled receptors (GPCRs) are critical targets in pharmaceutical research due to their roles in cellular signaling.
  • GPCRs represent a significant focus in drug discovery portfolios.
  • Developing effective small molecules for GPCRs remains a key challenge in medicinal chemistry.

Purpose of the Study:

  • To outline recent strategies employed for designing compound libraries specifically targeting GPCRs.
  • To discuss these GPCR compound library design strategies within a broader scientific context.
  • To provide insights into optimizing the discovery of novel GPCR-modulating agents.

Main Methods:

  • Review of proprietary compound library design methodologies.

Related Experiment Videos

  • Analysis of structure-activity relationships for GPCR ligands.
  • Comparative assessment of different library design approaches.

    • Main Results:

    • Presentation of novel design strategies for GPCR-focused compound libraries.
    • Discussion of key considerations in building effective GPCR screening collections.
    • Identification of promising avenues for future GPCR drug discovery efforts.

    Conclusions:

    • Strategic design of compound libraries is essential for successful GPCR drug discovery.
    • The discussed methodologies offer valuable frameworks for advancing GPCR research.
    • Continued innovation in library design will accelerate the identification of new therapeutics targeting GPCRs.