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Related Experiment Video

Updated: Jul 13, 2026

Quantifying Branching Density in Rat Mammary Gland Whole-mounts Using the Sholl Analysis Method

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Published on: July 12, 2017

Scatter factor-dependent branching morphogenesis: structural and histological features.

P Comoglio¹, L Trusolino, C Boccaccio

¹Division of Molecular Oncology, Institute for Cancer Research and Treatment (IRCC), University of Turin Medical School, Candiolo,Torino, Italy. paolo.comoglio@ircc.it

European Journal of Histochemistry : EJH

|August 21, 2007

Summary

Branching morphogenesis, crucial for organ development and cancer progression, is primarily driven by scatter factors. This review details their roles in normal development and disease, focusing on tissue structure changes.

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Area of Science:

Developmental Biology
Cell Biology
Oncology

Background:

Branching morphogenesis is a fundamental process forming complex organ structures like glands and blood vessels.
This process involves dynamic changes in cell polarity, adhesion, motility, and proliferation.
Aberrant branching morphogenesis contributes to cancer aggressiveness by promoting proliferation and invasion.

Purpose of the Study:

To review the biological and functional roles of scatter factors in branching morphogenesis.
To emphasize the phenotypic consequences of scatter factor activity in various tissues.
To link scatter factor function to both physiological development and pathological conditions like cancer.

Main Methods:

Literature review of studies on branching morphogenesis and scatter factors.
Analysis of scatter factor involvement in normal tissue development.
Examination of scatter factor roles in neoplastic cell behavior and cancer progression.

Main Results:

Scatter factors are key regulators of branching morphogenesis in both normal development and cancer.
These factors orchestrate cell polarity, adhesion, and motility crucial for tubule formation.
Dysregulated scatter factor activity enhances tumor cell proliferation, survival, and invasiveness.

Conclusions:

Scatter factors are essential mediators of branching morphogenesis across physiological and pathological contexts.
Understanding scatter factor mechanisms provides insights into organogenesis and cancer biology.
Targeting scatter factors may offer therapeutic strategies for developmental disorders and cancer.