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Updated: Jul 13, 2026

Biomimetic Materials to Characterize Bacteria-host Interactions
Published on: November 16, 2015
Single-step biocompatible coating for sulfhydryl coupling of receptors using 2-(pyridinyldithio)ethylcarbamoyl
Xin Li1, Christopher Abell, Matthew A Cooper
1Akubio Ltd., 181 Cambridge Science Park, Cambridge, United Kingdom.
Abstract:
2-(Pyridinyldithio)ethylcarbamoyl dextran (PDEC dextran) is developed herein as a novel biosensor coating material aimed for direct and facile fabrication of a sulfhydryl-specific capture surface on gold; the site-directed immobilization of a single free cysteine residue presented protein (human serum albumin, HSA) on PDEC dextran-coated surfaces without prior activation and subsequent specific binding of mouse monoclonal anti-HSA antibody to the resultant surface were demonstrated using surface plasmon resonance (SPR) assays.
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