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Updated: Jul 13, 2026

Analyzing Tumor and Tissue Distribution of Target Antigen Specific Therapeutic Antibody
Published on: May 16, 2020
The evolution of targeted biologic therapies
1Indiana University Cancer Center, Indiana Cancer Pavilion, RT-473, 535 Barnhill Dr., Indianapolis, IN 46202, USA. gsledge@iupui.edu
Abstract:
Targeted therapies for breast cancer reflect the underlying genomic complexity of the disease. These cancers, in turn, are Darwinian constructs, acting much like species undergoing mutational events, and with environmental pressures selecting evolutionary winners and losers. It is therefore reasonable to consider the evolution of targeted biologic therapies in classic evolutionary terms. This paper will examine breast cancer therapeutics in terms of species undergoing adaptational changes as a consequence on mutational events, and will examine the prospects for new therapeutic species.
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