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Related Experiment Video

Updated: Jul 13, 2026

Inducing Acute Liver Injury in Rats via Carbon Tetrachloride (CCl4) Exposure Through an Orogastric Tube

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Published on: April 28, 2020

Butachlor-induced acute toxic hepatitis.

Nasser Ebrahimi Daryani¹, Parviz Hosseini, Mohammad Bashashati

¹Endocrinology and Metabolism Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology

|August 21, 2007

Summary

Accidental skin exposure to the herbicide butachlor caused toxic hepatitis in a 60-year-old man. Symptoms resolved with conservative treatment, highlighting butachlor

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Area of Science:

Toxicology
Dermatology
Hepatology

Background:

Butachlor is a widely used herbicide in agriculture.
Occupational and accidental exposures can occur.
Understanding toxic effects is crucial for safety.

Observation:

A 60-year-old male presented with exfoliative dermatitis, jaundice, elevated liver enzymes, and eosinophilia.
Symptoms appeared one day after accidental dermal exposure to butachlor.
No other causative factors were identified.

Findings:

Diagnostic workup excluded other causes of liver injury.
Liver histology confirmed substance-induced toxic hepatitis.
Complete recovery of liver function tests within two weeks of conservative therapy.

Implications:

This case highlights the potential hepatotoxicity of butachlor following dermal exposure.
It underscores the importance of safety precautions during herbicide handling.
Prompt diagnosis and conservative management can lead to favorable outcomes.