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Chronic Pancreatitis I: Introduction

Chronic Pancreatitis I: Introduction

Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80% of...

Chronic Pancreatitis I: Introduction

Chronic Pancreatitis I: Introduction

The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...

Chronic Pancreatitis II: Pathophysiology

Chronic Pancreatitis II: Pathophysiology

Chronic pancreatitis is a progressive and irreversible inflammation of the pancreas, most often caused by long-term alcohol abuse, but it can also be related to ductal obstruction, smoking, or genetic factors.Chronic pancreatitis occurs when the pancreas is repeatedly exposed to harmful agents like alcohol, smoking, ductal obstruction, or genetic predisposition. These factors lead to the release of toxic metabolites and inflammatory cytokines, sustaining chronic inflammation in the pancreatic...

Acute Pancreatitis II: Pathophysiology

Acute Pancreatitis II: Pathophysiology

The pathophysiology of acute pancreatitis centers on injury to pancreatic acinar cells, which initiates a cascade of harmful intracellular events.This injury leads to premature activation of trypsinogen to trypsin in the pancreas. Trypsin then activates other digestive enzymes, such as chymotrypsin, elastase, and phospholipase A2, which begin breaking down pancreatic tissue. The resulting autodigestion causes local inflammation, tissue swelling, hemorrhage, and fat necrosis.Injured acinar cells...

Acute Pancreatitis I: Introduction

Acute Pancreatitis I: Introduction

Acute pancreatitis is the sudden inflammation of the pancreas caused by the early activation of digestive enzymes, leading to the autodigestion of pancreatic tissue. This results in local inflammation and, in severe cases, systemic complications.EtiologyUnderstanding the underlying causes is crucial, as identifying the etiology guides treatment and anticipates complications. Acute pancreatitis can be triggered by various factors, typically grouped into the following clinical categories.Biliary...

Acute Pancreatitis I: Introduction

Acute Pancreatitis I: Introduction

Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:

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Updated: Jul 13, 2026

An Obstructive Chronic Pancreatitis Model Established Through Electrocoagulation

An Obstructive Chronic Pancreatitis Model Established Through Electrocoagulation

Published on: October 31, 2025

Eosinophilic pancreatitis with pseudocyst.

K Rakesh¹, R Banerjee, R Gupta

¹Asian Institute of Gastroenterology, Somajiguda, Hyderabad, India.

Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology

|August 21, 2007

Summary

Eosinophilic pancreatitis, a rare condition, can manifest with systemic signs like peripheral eosinophilia. This case highlights a woman with acute pancreatitis, ascites, and pseudocyst linked to eosinophilia.

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Last Updated: Jul 13, 2026

An Obstructive Chronic Pancreatitis Model Established Through Electrocoagulation

An Obstructive Chronic Pancreatitis Model Established Through Electrocoagulation

Published on: October 31, 2025

Area of Science:

Gastroenterology
Immunology
Pathology

Background:

Eosinophilic pancreatitis is a rare pancreatic disease.
It is characterized by eosinophilic infiltration of the pancreas.
Often associated with systemic manifestations like peripheral eosinophilia and elevated serum IgE levels.

Observation:

A 38-year-old woman presented with symptoms suggestive of acute pancreatitis.
The patient exhibited peripheral eosinophilia, a key systemic manifestation.
Imaging revealed pancreatic ascites and a pseudocyst.

Findings:

The case demonstrates a direct association between peripheral eosinophilia and acute pancreatitis.
Eosinophilic infiltration of the pancreas was likely the underlying cause.
The presence of pancreatic ascites and pseudocyst are significant complications.

Implications:

This case underscores the importance of considering eosinophilic pancreatitis in patients with unexplained pancreatitis and eosinophilia.
Early diagnosis and management can prevent severe complications.
Further research into the pathogenesis and treatment of eosinophilic pancreatitis is warranted.