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Updated: Jul 13, 2026
miRNA Expression Analyses in Prostate Cancer Clinical Tissues
Published on: September 8, 2015
Molecular profiling and genomic microarrays in prostate cancer
Ch Golias1, A Charalabopoulos, D Stagikas
1Department of Physiology, Clinical Unit, Medical Faculty, University of Ioannina, Ioannina, Greece.
Abstract:
In the present review article a global approach regarding the usefulness of genomic microarrays in prostate cancer management, is attempted. Cancer is a multistep process of mutations in key regulatory genes and epigenetic alterations that result in loss of balanced gene expression. A complete knowledge of the interaction between the genetic variability of the neoformation (tumor profiling) and the genetic variability of the host (inherited genome profiling), will be able to determine the better strategy against the cancer and the less toxicity for the patient. Alterations in the sequence of the hormone binding domain of the androgen receptor as well as mutations in some genes, determine radioresistance and resistance or sensitivity to some chemotherapeutic drugs. New therapies using monoclonal antibodies directed against specific extracellular binding domains of some receptors are based on molecular alterations observed in tumors.
Insights
Genomic microarrays aid prostate cancer management by analyzing tumor and host genetic variations. This approach helps personalize treatment strategies, improving efficacy and reducing patient toxicity.
Area of Science:
- Oncology
- Genomics
- Molecular Biology
Background:
- Prostate cancer arises from genetic mutations and epigenetic changes disrupting gene expression.
- Understanding tumor and host genetic variability is crucial for effective cancer management.
- Androgen receptor alterations and gene mutations influence treatment response and resistance.
Purpose of the Study:
- To review the utility of genomic microarrays in prostate cancer management.
- To explore the integration of tumor profiling and host genome profiling for personalized therapy.
- To highlight the role of molecular alterations in guiding treatment decisions.
Main Methods:
- Review of current literature on genomic microarrays in prostate cancer.
- Analysis of genetic variability in tumor and host genomes.
- Correlation of molecular alterations with treatment response and resistance.
Main Results:
- Genomic microarrays offer a comprehensive approach to understanding prostate cancer complexity.
- Personalized treatment strategies can be developed by integrating tumor and host genetic data.
- Identification of specific molecular targets for novel therapies, including monoclonal antibodies.
Conclusions:
- Genomic microarrays are valuable tools for optimizing prostate cancer management.
- Integrating genetic profiling enhances the selection of effective and less toxic therapies.
- Molecular insights derived from genomic analysis pave the way for targeted treatment strategies.
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