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Terrequinone A biosynthesis through L-tryptophan oxidation, dimerization and bisprenylation

Carl J Balibar1, Annaleise R Howard-Jones, Christopher T Walsh

  • 1Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Ave., Boston, Massachusetts 02115, USA.

Nature Chemical Biology
|August 21, 2007
PubMed
Summary

Researchers elucidated the biosynthesis of the antitumor compound terrequinone A. They reconstituted the pathway in E. coli, revealing key enzymatic steps including L-tryptophan aminotransferase and prenyltransferase activities.

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