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A water-soluble "switching on" fluorescent chemosensor of selectivity to Cd2+
Weimin Liu1, Liwei Xu, Ruilong Sheng
1Laboratory of Organic Optoelectronic Functional Materials and Molecular Engineering, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, 100080, China.
Abstract:
Compound 1, a new fluorescent chemosensor signaling via significantly enhanced fluorescence when bound with cation analytes, was synthesized and characterized. This fluorescent chemosensor exhibits its selectivity to Cd2+ among a series of cations in HEPES buffer solution. Its in vitro sensitivity to Cd2+ was demonstrated in the HK-2 cell line with use of confocal microscopy. The mechanistic selectivity and sensitivity of compound 1 to Cd2+ was discussed on the basis of fluorescence, 1H NMR, and mass spectroscopic results.
