Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Endometriosis and genetic polymorphisms.

Henrik Falconer1, Thomas D'Hooghe, Gabriel Fried

  • 1Obstetrics and Gynecology, Karolinska Institute, Stockholm, Sweden.

Obstetrical & Gynecological Survey
|August 21, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Transforming endometrial cancer diagnosis: the case for molecular triage in abnormal uterine and post-menopausal bleeding.

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society·2026
Same author

Highlights from the 27th European Congress on Gynecological Oncology in Copenhagen: interview compilation of the ENYGO-IJGC editorial fellows.

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society·2026
Same author

Reply of the authors: Trial emulation and clinical trials.

Fertility and sterility·2026
Same author

Association between trial registration and reporting large treatment effects in randomized controlled trials of infertility interventions: a meta-epidemiological study.

Fertility and sterility·2026
Same author

Intrapatient variability in the number of retrieved oocytes and ovarian response categories between consecutive in vitro fertilization cycles.

Fertility and sterility·2026
Same author

Machine learning-enhanced gas sensor technology identifies ovarian and endometrial cancer of all stages through plasma volatile organic compound patterns.

EBioMedicine·2025
Same journal

Amniotic Fluid Embolism: A Silent Threat to Maternal Life- An Up-to-Date Comprehensive Review of the Pathophysiology, Diagnosis, and Outcome.

Obstetrical & gynecological survey·2026
Same journal

A System Review of Pathophysiology, Diagnosis, and Clinical Management of Intrauterine Adhesions.

Obstetrical & gynecological survey·2026
Same journal

Atrial Fibrillation and Atrial Flutter in Pregnancy: Epidemiology, Pathophysiology, and Management.

Obstetrical & gynecological survey·2026
Same journal

Heavy Menstrual Bleeding in the Gynecology Clinic: A Call for Awareness and Standardized Screening for Underlying Bleeding Disorders.

Obstetrical & gynecological survey·2026
Same journal

Uterine Sarcomas: Clinical Management and a Review of Systemic Therapy.

Obstetrical & gynecological survey·2026
Same journal

Female Sexual Dysfunction: Current Models and Treatment Options.

Obstetrical & gynecological survey·2026
See all related articles

Genetic variations, or polymorphisms, show mixed results in linking to endometriosis development. While some gene associations appear stronger, overall, their value in predicting endometriosis risk is limited.

Area of Science:

  • Gynecology
  • Genetics
  • Pathophysiology

Background:

  • Endometriosis is a common benign gynecological condition with unknown causes.
  • Genetic polymorphisms are being investigated as potential contributing factors.
  • Existing research presents conflicting findings regarding these associations.

Purpose of the Study:

  • To review and summarize current data on gene polymorphisms and their association with endometriosis.
  • To highlight the complexity and variability of research findings.
  • To assess the clinical significance of identified single nucleotide polymorphisms (SNPs).

Main Methods:

  • A comprehensive literature search was conducted on PubMed using keywords 'endometriosis' and 'polymorphism'.
  • 108 publications from 1979 to 2005 were analyzed.

Related Experiment Videos

  • Studies were categorized by polymorphism type and association results.

    • Main Results:

    • Approximately 50% of studies showed a positive correlation between various polymorphisms and endometriosis.
    • Stronger correlations were observed in groups related to cytokines, inflammation, steroid metabolism, estradiol metabolism, and adhesion molecules.
    • Groups including hormone receptors, growth factors, and human leukocyte antigen components also showed significant associations.

    Conclusions:

    • The link between genetic polymorphisms and endometriosis is complex and characterized by conflicting results.
    • The value of single nucleotide polymorphisms (SNPs) in assessing endometriosis risk appears limited.
    • Research findings are often population-specific, requiring careful interpretation.