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Relationship between the adipose-tissue hormone resistin and coronary artery disease
Guenter Hoefle1, Christoph H Saely, Lorenz Risch
1Department of Medicine, Academic Teaching Hospital Feldkirch, A-6807 Feldkirch, Austria. vivit@lkhf.at
Insights
Serum resistin, a hormone linked to adipose tissue, shows correlations with age, hsCRP, and kidney function in coronary patients. However, resistin levels do not predict coronary artery disease presence or future vascular events.
Area of Science:
- Cardiovascular Medicine
- Endocrinology
- Biomarkers
Background:
- Limited data exists on the cardiovascular risk associated with resistin, an adipose-tissue-related hormone.
- Understanding resistin's role is crucial for assessing cardiovascular risk in patients.
Purpose of the Study:
- To investigate the association between serum resistin levels and cardiovascular risk factors.
- To determine if resistin predicts the presence and future incidence of vascular events in patients undergoing coronary angiography.
Main Methods:
- Serum resistin and vascular risk factors were measured in 547 patients undergoing coronary angiography.
- Major coronary and cumulative vascular events were prospectively recorded over a 4-year period.
Main Results:
- Serum resistin correlated with age, hsCRP, and declining renal function.
- No significant difference in resistin levels was found between patients with and without coronary artery disease (CAD) or significant coronary stenoses.
- Resistin levels did not predict major coronary events or cumulative vascular events in prospective analyses.
Conclusions:
- In patients with coronary artery disease, serum resistin is associated with hsCRP, age, and renal function.
- Resistin is not associated with the presence of significant coronary stenoses.
- Resistin does not predict future vascular events in this patient cohort.
Background:
Data on the cardiovascular risk associated with the adipose-tissue-related hormone resistin are scarce.
Methods:
We measured serum resistin and established vascular risk factors in 547 consecutive patients (age 63+/-10 years) undergoing coronary angiography for the evaluation of stable coronary artery disease. Prospectively, we recorded major coronary events and cumulative vascular events over 4 years.
Results:
60% of our patients had significant coronary stenoses with a lumen narrowing > or =50%. Serum resistin was moderately but significantly correlated with age (r=0.139; p=0.001), high-sensitivity C-reactive protein (hsCRP; r=0.228; p<0.001) and decreasing renal function (r=0.240; p<0.001). However, there was no significant difference of serum resistin between patients with CAD and those in whom angiography did not show CAD (4.5 [3.1-5.8] vs. 4.3 [3.4-5.3] ng/ml; p=0.545) and between patients with > or =50% coronary narrowings and those without such lesions (4.5 [3.2-5.9] vs. 4.3 [3.1-5.5] ng/ml; p=0.265). Prospectively, Cox regression analyses neither indicated an association between serum resistin and major coronary events nor between serum resistin and cumulative vascular events.
Conclusions:
Among coronary patients serum resistin is significantly correlated with hsCRP, age and decreasing renal function but resistin is neither associated with the presence of significant coronary stenoses nor with the incidence of future vascular events.
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