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[Clinical study of respiratory infections complicating bronchial asthma]

M Konishi1, M Sawaki, K Mikasa

  • 1Second Department of Internal Medicine, Nara Medical University.

Nihon Kyobu Shikkan Gakkai Zasshi
|November 1, 1991
PubMed

Insights

Respiratory infections complicate bronchial asthma, with H. influenzae frequently identified. While antibiotics reduced inflammation, they had limited impact on asthma symptoms, suggesting a complex role for infection.

Area of Science:

  • Clinical Medicine
  • Pulmonology
  • Infectious Diseases

Background:

  • Bronchial asthma is a chronic respiratory condition.
  • Respiratory infections can exacerbate asthma symptoms.
  • The specific role of bacterial pathogens in complicated asthma requires further elucidation.

Purpose of the Study:

  • To investigate the role of respiratory infections in patients with complicated bronchial asthma.
  • To identify common pathogens involved in these infections.
  • To assess the impact of antimicrobial therapy on inflammatory markers and asthma symptoms.

Main Methods:

  • Clinical study involving 22 patients with bronchial asthma.
  • Transtracheal aspiration (TTA) performed 37 times for sample collection.
  • Microbiological analysis to identify causative organisms.
  • Monitoring of inflammatory indices (white blood cell count, ESR) and asthma symptoms.

Main Results:

  • Haemophilus influenzae was the most frequently isolated organism.
  • Patients with identified organisms showed high incidence of fever and inflammation.
  • Antimicrobial therapy reduced inflammatory markers but showed limited efficacy against asthmatic symptoms.

Conclusions:

  • Respiratory infections, particularly H. influenzae, are significant in complicated bronchial asthma.
  • Inflammation associated with infection can be managed with antibiotics.
  • Infection plays a complex role in the clinical presentation of bronchial asthma, impacting symptoms beyond inflammation.

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