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Primary Lymphoid Organs

Primary Lymphoid Organs

Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...

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Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
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Secondary Lymphoid Organs

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Updated: Jul 13, 2026

An Efficient and Simple Method to Establish NK and T Cell Lines from Patients with Chronic Active Epstein-Barr Virus Infection

An Efficient and Simple Method to Establish NK and T Cell Lines from Patients with Chronic Active Epstein-Barr Virus Infection

Published on: March 30, 2018

Epstein-Barr virus-associated lymphoproliferative disorders.

Sherif A Rezk¹, Lawrence M Weiss

¹Department of Pathology, City of Hope National Medical Center, Duarte, CA 91010, USA.

Human Pathology

|August 21, 2007

Summary

Epstein-Barr virus (EBV), a human herpesvirus, causes infectious mononucleosis and is linked to various cancers. This review focuses on EBV-associated lymphoproliferative disorders in B-cells, T/NK-cells, and HIV patients.

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Establishment of Epstein-Barr Virus Growth-transformed Lymphoblastoid Cell Lines

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Published on: November 8, 2011

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Last Updated: Jul 13, 2026

An Efficient and Simple Method to Establish NK and T Cell Lines from Patients with Chronic Active Epstein-Barr Virus Infection

An Efficient and Simple Method to Establish NK and T Cell Lines from Patients with Chronic Active Epstein-Barr Virus Infection

Published on: March 30, 2018

Establishment of Epstein-Barr Virus Growth-transformed Lymphoblastoid Cell Lines

Establishment of Epstein-Barr Virus Growth-transformed Lymphoblastoid Cell Lines

Published on: November 8, 2011

Area of Science:

Virology
Oncology
Immunology

Background:

Epstein-Barr virus (EBV) is a human herpesvirus discovered in 1964.
EBV is the primary cause of infectious mononucleosis.
EBV is associated with numerous human cancers, including hematopoietic, epithelial, and mesenchymal tumors.

Purpose of the Study:

To review Epstein-Barr virus-associated lymphoproliferative disorders.
To categorize these disorders into B-cell, T/NK-cell, and HIV-related groups.

Main Methods:

Literature review of EBV-associated lymphoproliferative disorders.
Classification based on cell type (B-cell, T/NK-cell) and HIV association.

Main Results:

EBV is implicated in various lymphoproliferative disorders.
These disorders can affect B-cells, T-cells, and NK-cells.
HIV infection increases the risk of EBV-associated lymphoproliferative disorders.

Conclusions:

EBV plays a significant role in lymphoproliferative disorders.
Understanding these distinctions is crucial for diagnosis and treatment.
Further research is needed to explore therapeutic strategies for EBV-related conditions.