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Increased circulating monocyte count is related to good collateral development in coronary artery disease

Sinan Altan Kocaman1, Uğur Arslan, Yusuf Tavil

  • 1Gazi University School of Medicine, Department of Cardiology, Besevler, 06500 Ankara, Turkey. sinanaltan@gmail.com

Atherosclerosis
|August 21, 2007
PubMed

Insights

Higher circulating monocyte counts are linked to better coronary collateral development in patients with severe coronary artery disease (CAD). This finding may improve understanding of cardiovascular medicine.

Area of Science:

  • Cardiology
  • Immunology
  • Vascular Biology

Background:

  • Monocytes play a key role in collateral growth, as shown in animal models.
  • Collateral circulation is crucial for supplying blood to ischemic tissues in coronary artery disease (CAD).

Purpose of the Study:

  • To investigate the association between circulating monocyte count and collateral development in patients with severely stenotic CAD.
  • To determine if monocyte levels can predict collateralization in CAD patients.

Main Methods:

  • Analysis of coronary angiograms from 210 patients with >=95% stenosis in a major coronary artery.
  • Classification of collateral development as good (103 patients) or poor (107 patients) using the Cohen-Rentrop method.
  • Multivariate analysis to compare monocyte counts between the two groups.

Main Results:

  • A significantly higher monocyte count was observed in patients with good collateral development (671+/-218 mm(-3)) compared to those with poor collateral development (522+/-195 mm(-3), p<0.001).
  • Increased monocyte count was independently associated with good collateral development (Odds Ratio [OR], 2.918; 95% Confidence Interval [CI], 1.281-6.648; p=0.011).

Conclusions:

  • Circulating monocyte count is a significant predictor of collateral development in patients with severe CAD.
  • This finding highlights the clinical and basic importance of monocytes in cardiovascular medicine and collateralization.

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