Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Bacterial toxins and Multiple Sclerosis.

Frederick Gay1

  • 1Cambridge Biostability, NIAB, Cambridge, UK. fwg@greenstorthe.freeserve.co.uk

Journal of the Neurological Sciences
|August 21, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clinical characteristics and treatments of imported loiasis patients with microfilaraemia diagnosed in France, 2000-2022.

Travel medicine and infectious disease·2026
Same author

Taxonomic assessment of phlebotomine sand flies in Southeast Asia based on records from Cambodia.

Current research in parasitology & vector-borne diseases·2026
Same author

Estimation of the magnitude of plastic and chemical pollution related to the abandonment of insecticide treated nets in the environment: From a KAP survey conducted in Benin in July 2023.

Travel medicine and infectious disease·2025
Same author

Post-artesunate Delayed Hemolysis in African Children With Severe Malaria: Incidence, Medical Impact and Prevention.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2025
Same author

Might procalcitonin help predict imported falciparum malaria in children?

Travel medicine and infectious disease·2024
Same author

The risk of multiple sclerosis on the Orkney islands. A review of the search for distinctively Orcadian risks, with a hypothesis for further investigations.

Multiple sclerosis and related disorders·2024
Same journal

Distinguishing drug-target effects from natural lipid variation and incorporating imaging outcomes in Mendelian randomisation studies of multiple sclerosis.

Journal of the neurological sciences·2026
Same journal

Long-term social cognitive impairment after ischemic stroke: Frequency and association with lesion volume and location in an exploratory pilot study.

Journal of the neurological sciences·2026
Same journal

Subjective cognitive decline among U.S. Cancer survivors, 2017-2024: Prevalence, cancer-specific patterns, and associated factors.

Journal of the neurological sciences·2026
Same journal

Comment on "Comparative impact of mental and cardiovascular comorbidities on adverse outcomes in people with MS".

Journal of the neurological sciences·2026
Same journal

Comment on "Efficacy and safety of conventional immunosuppressant therapies in elderly patients with Neuromyelitis optica spectrum disorder: A target trial emulation study".

Journal of the neurological sciences·2026
Same journal

Increasing incidence of varicella-zoster virus meningitis in Japan, 2011-2022.

Journal of the neurological sciences·2026
See all related articles

Bacterial toxins may play a role in Multiple Sclerosis (MS) pathogenesis. Nasopharyngeal infections could introduce toxins into the Central Nervous System (CNS) via unique pathways, potentially explaining MS development.

Area of Science:

  • Neuroimmunology
  • Infectious Disease

Background:

  • Multiple Sclerosis (MS) is characterized by Central Nervous System (CNS) demyelination.
  • The precise cause of MS remains elusive despite extensive research.
  • Charcot's early descriptions of MS lesions highlight the disease's long-standing mystery.

Purpose of the Study:

  • To review the potential role of bacterial molecules and toxins in MS pathogenesis.
  • To explore the link between nasopharyngeal infections and neurological conditions like MS.
  • To investigate alternative pathways for CNS entry of pathogens and toxins.

Main Methods:

  • Review of historical and contemporary data linking bacterial infections to MS.
  • Examination of the blood-brain barrier and its potential bypass routes.

Related Experiment Videos

  • Analysis of the lymphatic drainage system connecting the nasopharynx to the CNS.

    • Main Results:

    • Bacterial toxins can disrupt immunity and damage the nervous system.
    • Nasopharyngeal infections have been historically linked to optic neuritis and MS.
    • A bidirectional link exists between cerebrospinal fluid (CSF) and nasopharyngeal lymphatic drainage, allowing pathogen entry.

    Conclusions:

    • Bacterial products from nasopharyngeal infections may enter the CNS via CSF and lymphatic pathways.
    • These products could be processed by immune cells in the meninges and perivascular spaces.
    • Identifying bacterial toxins in early MS tissues could revolutionize understanding of MS pathogenesis.